Beyond COVID-19: Do biothermodynamic properties allow predicting the future evolution of SARS-CoV-2 variants?Research article Published on 2022-12-012022-10-05 Journal: Microbial Risk Analysis [Category] 변종, [키워드] Analysis binding biological property changes in COVID-19 pandemic driving Epidemiological study Evolution Evolution of SARS-CoV-2 Gibbs energy of binding Gibbs energy of growth growth Mechanistic model MERS-CoV Mutation new strain new virus Occurrence pandemic parameter performed predict risk SARS CoV-2 SARS-CoV statistical Strains the SARS-CoV-2 variants of SARS-CoV-2 Virus-host interaction viruses [DOI] 10.1016/j.mran.2022.100232 [Article Type] Research article
Variation in SARS-CoV-2 seroprevalence in children in the region of Asturias, Northern SpainArticle Published on 2022-12-012022-11-15 Journal: World Journal of Pediatrics [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome analyzed antibodies Asturias change Child children close contact collected Contact tracing coronavirus coronavirus disease COVID-19 epidemiological estimate Evolution of SARS-CoV-2 Factor fatigue Features longitudinal change median age multicenter multivariable analysis occurred positive Prospective public health recruited SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody test SARS-CoV-2 seroprevalence seroepidemiologic studies. seronegative seropositive Spain subject Symptom Symptoms variable venous blood Virological virological test [DOI] 10.1007/s12519-022-00617-2 PMC 바로가기
SARS-CoV-2 quasi-species analysis from patients with persistent nasopharyngeal sheddingArticle Published on 2022-11-042022-11-16 Journal: Scientific Reports [Category] SARS, 변종, [키워드] Analysis asked both groups clade Consequences Control COVID 19 deviation Evolution of SARS-CoV-2 genomic greater Human immune system immune evasion increase Infectious virus Interaction intra-individual investigated Mutation N501Y nasopharyngeal no significant difference P681H pandemic Patient patients performed persistence Prevent question RNA virus SARS-CoV-2 Sequencing Standard survival the SARS-CoV-2 therapeutic two group Variability variants viral propagation viral variant [DOI] 10.1038/s41598-022-22060-z PMC 바로가기
Monitoring the evolution of SARS-CoV-2 on a Spanish university campus through wastewater analysis: A pilot project for the reopening strategyArticle Published on 2022-11-012022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition administration carried Christma collected conducted COVID-19 COVID-19 incidence defined Epidemiology Evolution Evolution of SARS-CoV-2 Frequency implementation improvement knowledge monitoring Mutation occurred outbreak pandemic populations Probability returned SARS-CoV-2 SARS-CoV-2 RNA detection selected Sequencing sewage Spain Spanish Surveillance symptomatic and asymptomatic transmission of SARS-CoV-2 university University campus viral variant virus virus variants wastewater Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.157370 PMC 바로가기
Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domainArticle Published on 2022-10-132022-11-15 Journal: Cell [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 binding antibody antibody treatment artificial intelligence COVID-19 COVID-19 pandemic deep deep learning deep sequencing develop directed evolution domain Evolution of SARS-CoV-2 machine learning mutated variant Mutation mutations Neutralizing antibodies neutralizing antibody omicron predict Predictive Protein protein engineering RBD RBD variants representing SARS-CoV-2 variant Selection sequence the SARS-CoV-2 therapeutic Trajectories Vaccine variant variants viral escape viral spike protein yeast yeast display. [DOI] 10.1016/j.cell.2022.08.024 PMC 바로가기
Dynamic SARS-CoV-2 emergence algorithm for rationally-designed logical next-generation vaccinesArticle Published on 2022-10-102022-11-15 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Algorithm amino acid substitution change Clinical efficacy clinical sample correlation D614G decrease determine dynamic Efficacy Endemic epitope Epitopes Evolution Evolution of SARS-CoV-2 immune immunogenic indicated lineages mAb monitoring monoclonal antibodies Mutation mutations Pearson positive positive correlation predicted Predictive Prevalence prevalent resulting SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome spike mutation Spike protein Spread Substitution Vaccine Vaccine design variant virus [DOI] 10.1038/s42003-022-04030-3 PMC 바로가기
As the virus evolves, so too must we: a drug developer’s perspective : We need a new paradigm in searching for next-generation countermeasuresArticle Published on 2022-10-102022-11-15 Journal: Virology Journal [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] addition antibody Antiviral approach cellular immunity COVID19 develop drug drug resistance drugs Effect effective Evolution of SARS-CoV-2 Genetic greater HAD HDTx host-directed antiviral Host-directed therapeutics humoral immune immune evasion in sight infections offer omicron Pandemic countermeasures Perspective plasticity population immunity Quasispecies recombinant reduce risk SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virus SARS-CoV-2. selective severity strain Treatment Vaccine variant variants virus [DOI] 10.1186/s12985-022-01887-y PMC 바로가기
Validation of reduced S-gene target performance and failure for rapid surveillance of SARS-CoV-2 variantsArticle Published on 2022-10-032022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] acute infection AEGIS amplification anomalies B.1.1.529 cause changes in characteristic conducted Corporation COVID-19 COVID-19 test Critical diagnose diagnostic diagnostic PCR tests effective Ensuring Evolution of SARS-CoV-2 Lineage lineages molecular Mutation observation omicron Patient PCR PCR testing Pharmacy polymerase chain proportion public health reduced reverse transcription RT-PCR S-gene SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Science Sequencing Surveillance the United State Transmission validation variant variants Viral transmission virus Walgreen whole genome [DOI] 10.1371/journal.pone.0275150 PMC 바로가기
Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19Research article Published on 2022-10-012022-10-05 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] acute respiratory syndrome Antiviral antiviral activity Antiviral treatment B.1.351 B.1.617.2 Beta Brequinar cellular Combination coronavirus coronavirus disease COVID-19 de novo deaths Delta DHODH Dihydroorotate dehydrogenase (DHODH) Dipyridamole drug treatments effective enzyme evade Evolution of SARS-CoV-2 exhibit global pandemic Host host cell in vitro Infection infections inhibitor maintain medical need monoclonal antibody nucleotide pathway rationale Replication required resulting RNA virus SARS-CoV-2 SARS-COV-2 infection selective shown Support synergistic therapy treat Treatment Vaccine variants viral replication [DOI] 10.1016/j.antiviral.2022.105403 [Article Type] Research article
Comparison of viral propagation and drug response among SARS-CoV-2 VOCs using replicons capable of recapitulating virion assembly and releaseArticle Published on 2022-10-012022-11-15 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome assays Beta changed coronavirus Delta delta VoCs drug resistance drug response ENhance Evolution of SARS-CoV-2 genomes immune evasion inhibitor manifested Mutation novel antiviral drugs Protein provide quantification released remained Remdesivir replicon RNA S gene SARS-CoV-2 sgRNA supernatant Support Transcription variants variants of concern variants of concern (VOC) viral genome replication viral infectivity viral life cycle viral propagation Viral protein Viral-like particle (VLP). viral-like particles virion assembly VLP VoC VOCs WIV04 strain [DOI] 10.1016/j.virs.2022.06.008 PMC 바로가기